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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG1
All Species:
23.33
Human Site:
S739
Identified Species:
46.67
UniProt:
P19174
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19174
NP_002651.2
1290
148532
S739
D
S
L
V
D
L
I
S
Y
Y
E
K
H
P
L
Chimpanzee
Pan troglodytes
XP_514650
1630
185027
S1079
D
S
L
V
D
L
I
S
Y
Y
E
K
H
P
L
Rhesus Macaque
Macaca mulatta
XP_001087295
1291
148567
S739
D
S
L
V
D
L
I
S
Y
Y
E
K
H
P
L
Dog
Lupus familis
XP_542998
1249
143812
S699
D
S
L
V
D
L
I
S
Y
Y
E
K
H
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q62077
1302
149650
S739
D
S
L
V
D
L
I
S
Y
Y
E
K
H
P
L
Rat
Rattus norvegicus
P10686
1290
148530
S739
D
S
L
V
D
L
I
S
Y
Y
E
K
H
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q2VRL0
637
72514
M140
F
E
G
F
I
R
Y
M
S
S
E
D
C
T
I
Frog
Xenopus laevis
Q32NH8
758
87399
L261
P
S
D
T
A
K
K
L
H
A
M
S
I
D
G
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
M287
W
A
Q
K
N
L
F
M
T
Q
N
G
F
T
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13217
1095
124845
N598
Q
S
S
I
D
F
V
N
Y
N
K
R
Q
M
S
Honey Bee
Apis mellifera
XP_624101
1134
132613
K637
F
R
A
E
N
K
I
K
H
C
R
I
K
L
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
Y443
T
V
K
A
L
Y
D
Y
K
A
Q
R
E
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79
99.5
93.2
N.A.
95.3
96.9
N.A.
N.A.
21.4
21.7
21.8
N.A.
21.4
45.1
N.A.
35.1
Protein Similarity:
100
79
99.7
94.5
N.A.
96.7
98.2
N.A.
N.A.
32.4
37.3
36.3
N.A.
40
62
N.A.
50
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
6.6
6.6
6.6
N.A.
20
6.6
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
13.3
13.3
26.6
N.A.
53.3
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
9
9
0
0
0
0
17
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
9
0
0
9
0
0
% C
% Asp:
50
0
9
0
59
0
9
0
0
0
0
9
0
17
0
% D
% Glu:
0
9
0
9
0
0
0
0
0
0
59
0
9
0
17
% E
% Phe:
17
0
0
9
0
9
9
0
0
0
0
0
9
0
0
% F
% Gly:
0
0
9
0
0
0
0
0
0
0
0
9
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
17
0
0
0
50
0
0
% H
% Ile:
0
0
0
9
9
0
59
0
0
0
0
9
9
0
9
% I
% Lys:
0
0
9
9
0
17
9
9
9
0
9
50
9
0
0
% K
% Leu:
0
0
50
0
9
59
0
9
0
0
0
0
0
9
50
% L
% Met:
0
0
0
0
0
0
0
17
0
0
9
0
0
9
9
% M
% Asn:
0
0
0
0
17
0
0
9
0
9
9
0
0
0
0
% N
% Pro:
9
0
0
0
0
0
0
0
0
0
0
0
0
50
0
% P
% Gln:
9
0
9
0
0
0
0
0
0
9
9
0
9
0
0
% Q
% Arg:
0
9
0
0
0
9
0
0
0
0
9
17
0
0
0
% R
% Ser:
0
67
9
0
0
0
0
50
9
9
0
9
0
0
9
% S
% Thr:
9
0
0
9
0
0
0
0
9
0
0
0
0
17
0
% T
% Val:
0
9
0
50
0
0
9
0
0
0
0
0
0
0
0
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
9
9
59
50
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _